Detection of fibrous cap in atherosclerotic plaque by intravascular ultrasound by use of color mapping of angle-dependent echo-intensity variation.

نویسندگان

  • T Hiro
  • T Fujii
  • K Yasumoto
  • T Murata
  • A Murashige
  • M Matsuzaki
چکیده

BACKGROUND The thickness of the fibrous cap is a major determinant in the vulnerability of atherosclerotic plaque to rupture. It has been demonstrated that intravascular ultrasound (IVUS) backscatter from fibrous tissue is strongly dependent on the ultrasound beam angle of incidence. This study investigated the feasibility of using a new IVUS color mapping technique representing the angle-dependent echo-intensity variation to determine the thickness of the fibrous cap in atherosclerotic plaque. METHODS AND RESULTS Nineteen formalin-fixed noncalcified human atherosclerotic plaques from necropsy were imaged in vitro with a 30-MHz IVUS catheter. The IVUS catheter was moved coaxially relative to the plaque. The images showing maximum and minimum echo intensity of the plaque surface were selected to calculate the angle-dependent echo-intensity variation. A colorized representation of the echo-intensity variation in the plaque was obtained from the 2 IVUS images. A clearly bordered area with large variation in echo intensity was revealed for each plaque surface in the colorized IVUS image. The thickness (x, mm) of this area correlated significantly with that of fibrous cap (y, mm) measured from histologically prepared sections as y=1.05x-0.01 (r=0.81, P:<0.0001). Bland-Altman analysis also supported the reliability of this method (mean difference, 0.00+/-0.10 mm). CONCLUSIONS This novel technique for color mapping the echo-intensity variation in IVUS provided an accurate representation of the thickness of the fibrous cap in atherosclerotic plaque. This method may be useful in assessing plaque vulnerability to rupture in atherosclerosis.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Intravascular modalities for detection of vulnerable plaque: current status.

Progress in the diagnosis, treatment, and prevention of atherosclerotic coronary artery disease is dependent on a greater understanding of the mechanisms of coronary plaque progression. Autopsy studies have characterized a subgroup of high-risk, or vulnerable, plaques that result in acute coronary syndromes or sudden cardiac death. These angiographically modest plaques share certain pathologic ...

متن کامل

Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels.

It is likely that factors other than stenosis severity predispose some atherosclerotic plaques to rupture. Because focal increases in circumferential stress may be an important mechanism of plaque rupture, we examined peak circumferential stress of atherosclerotic lesions by using finite element analysis based on idealized two-dimensional cross sections of diseased vessels similar to intravascu...

متن کامل

Renal artery atherosclerotic plaque ruptures visualised with intravascular ultrasound.

Renal angiography frequently yields indeterminate results (particularly in aneurysms), that in coronaries were found to be plaque rupture sites. In this setting, use of intravascular ultrasound (IVUS) allows unique insights into actual lesion anatomy. We present three cases with striking in-vivo IVUS visualisation of renal artery atherosclerotic plaque rupture. Panels A, B, and C show three dis...

متن کامل

Intravascular ultrasound tissue characterization. I like the rainbow but...what's behind the colours?

Intravascular ultrasound (IVUS) remains the gold standard for, precise, high-quality visualization of atherosclerotic plaque on the vessel wall. Conventional grey-scale IVUS provides unique insights into the underlying substrate of atherosclerotic disease, and classical studies have demonstrated that plaque echogenicity correlated with its histological composition. However, despite its ability ...

متن کامل

Characterization of plaque components with intravascular ultrasound elastography in human femoral and coronary arteries in vitro.

BACKGROUND The composition of plaque is a major determinant of coronary-related clinical syndromes. Intravascular ultrasound (IVUS) elastography has proven to be a technique capable of reflecting the mechanical properties of phantom material and the femoral arterial wall. The aim of this study was to investigate the capability of intravascular elastography to characterize different plaque compo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Circulation

دوره 103 9  شماره 

صفحات  -

تاریخ انتشار 2001